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Thermosensitive Polymers and Thermo-Responsive Liposomal Drug Delivery Systems
Abuwatfa, Waad Hussein Awad, Nahid S. Pitt, William G. Husseini, Ghaleb
Abuwatfa, Waad Hussein
Awad, Nahid S.
Pitt, William G.
Husseini, Ghaleb
Date
2022
Advisor
Type
Article
Peer-Reviewed
Published version
Peer-Reviewed
Published version
Degree
Description
Abstract
Temperature excursions within a biological milieu can be effectively used to induce drug release from thermosensitive drug-encapsulating nanoparticles. Oncological hyperthermia is of particular interest, as it is proven to synergistically act to arrest tumor growth when combined with optimally-designed smart drug delivery systems (DDSs). Thermoresponsive DDSs aid in making the drugs more bioavailable, enhance the therapeutic index and pharmacokinetic trends, and provide the spatial placement and temporal delivery of the drug into localized anatomical sites. This paper reviews the fundamentals of thermosensitive polymers, with a particular focus on thermoresponsive liposomal-based drug delivery systems.