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Liposomal Encapsulation of Chemotherapeutics Agents Combined with the Use of Ultrasound in Cancer Treatment
Almajed, Zeyad Mohamed AlSawaftah, Nour Majdi Sulieman, Hana Husseini, Ghaleb
Almajed, Zeyad Mohamed
AlSawaftah, Nour Majdi
Sulieman, Hana
Husseini, Ghaleb
Date
2023-07
Advisor
Type
Article
Peer-Reviewed
Published version
Peer-Reviewed
Published version
Degree
Description
Abstract
Ultrasound (US) has numerous uses in the medical field, including imaging, tumor ablation, and lithotripsy; another interesting application of US in cancer therapy is as an external trigger in targeted drug delivery. Cancer-targeted drug delivery involves delivering chemotherapeutic drugs to tumor sites with a high degree of precision, which would minimize the adverse side effects experienced by patients. Several nanocarriers have been studied as possible nanocarriers; however, liposomes stood out from the rest because of their non-immunogenicity, amphiphilic nature, ease of functionalization, and stimuli-responsiveness. This review addresses the role of US in the synthesis of liposomes, its ability to induce localized and controlled drug release from liposomes, as well as the integration of US-induced release and US-imaging using liposomes as contrast agents utilizing thermal and/or mechanical effects.