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Improving the Efficacy of Anticancer Drugs via Encapsulation and Acoustic Release
Ahmed, Salma E. Awad, Nahid S. Paul, Vinod Moussa, Hesham Gamal Husseini, Ghaleb
Ahmed, Salma E.
Awad, Nahid S.
Paul, Vinod
Moussa, Hesham Gamal
Husseini, Ghaleb
Date
2018
Advisor
Type
Peer-Reviewed
Article
Postprint
Article
Postprint
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Description
Abstract
Conventional chemotherapeutics lack the specificity and controllability, thus may poison healthy cells while attempting to kill cancerous ones. Newly developed nano-drug delivery systems have shown promise in delivering anti-tumor agents with enhanced stability, durability and overall performance; especially when used along with targeting and triggering techniques. This work traces back the history of chemotherapy, addressing the main challenges that have encouraged the medical researchers to seek a sanctuary in nanotechnological-based drug delivery systems that are grafted with appropriate targeting techniques and drug release mechanisms. A special focus will be directed to acoustically triggered liposomes encapsulating doxorubicin.