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The Kinetics of Calcein Release from Mixed Targeted Liposomes Using Ultrasound
AlSawaftah, Nour Majdi Husseini, Ghaleb Pitt, William G.
AlSawaftah, Nour Majdi
Husseini, Ghaleb
Pitt, William G.
Date
2022
Advisor
Type
Article
Peer-Reviewed
Postprint
Peer-Reviewed
Postprint
Degree
Citations
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Description
Abstract
Site-specific delivery of chemotherapeutics using actively targeted-stimuli-responsive liposomes is a promising approach to enhance the therapeutic efficiency of anti-cancer drugs while reducing the associated undesirable side effects. Recently, the co-functionalization of liposomes has shown interesting results in enhancing cellular uptake; however, such systems suffer from stability issues. This study proposes mixing calcein-loaded liposomes decorated with different ligands, namely estrone and Herceptin, to treat breast cancer. We investigated the low-frequency ultrasound-mediated release of calcein from the synthesized liposomes (control, estrone-modified, Herceptin-modified, and mixed estrone and Herceptin liposomes at different volume fractions). The results showed that the release increased as the power density increased and that estrone-conjugated liposomes achieved the highest release under all test conditions.