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Sodium Alginate Coated Metal Organic Framework For Near Infrared Triggered Release
Nasrin, Jubaydah
Nasrin, Jubaydah
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Description
A Master of Science thesis in Chemical Engineering by Jubaydah Nasrin entitled, “Sodium Alginate Coated Metal Organic Framework For Near Infrared Triggered Release”, submitted in December 2024. Thesis advisor is Dr. Rana Sabouni. Soft copy is available (Thesis, Completion Certificate, Approval Signatures, and AUS Archives Consent Form).
Abstract
Researchers are actively exploring novel approaches to administer chemotherapy medications more effectively with fewer adverse side effects. Therein, the use of polymer coated metal-organic frameworks, MOFs, are a viable option for pH and light-responsive nanocarriers in controlled drug delivery due to their distinctive physicochemical characteristics. The polymer coated MOF maximizes the synergistic antitumor impact by combining the benefits of physiological stability, tumor microenvironment pH responsiveness, and high drug encapsulation efficiency while simultaneously transporting drugs to the cancerous cells. In this study, commercially synthesized NH₂-MIL-125(Ti), a titanium-based MOF with a BET surface area of 847 m²/g, was coated with sodium alginate (SA) polymer on the crystal lattice of the nanocomposite after the encapsulation of doxorubicin (DOX). The drug release efficiency of SA/DOX@NH₂-MIL-125(Ti) nanocomposite at two different pH levels of 5.3 and 7.4 was investigated with irradiation of Near-infrared Light (NIR) as an external stimulus. Remarkably, the NH₂-MIL-125(Ti) nanocarrier achieved a high encapsulation efficiency of 94% where the drug release of DOX increased in pH level of 5.3 from 7.7% (control) to 51% (NIR-light), whereas at pH 7.4, 9% released in control and only 39% under NIR-light. Reactive Oxygen Species (ROS) test confirmed that the NH₂-MIL-125(Ti) produces good amount of OH radicals under the NIR radiation which is confirmed by the visible blue colour of the solution mixture and a high absorbance peak at 650 nm. Various characterization tests were also conducted to analyze the material such as FTIR where the stretching vibration of C=O bond of DOX at 1650 cm⁻¹ indicated the successful loading of DOX onto the nanocarrier. SEM results showed that the nanocarrier had coarse granular particle with size around 300 nm. XRD results showed that the NH₂-MIL-125(Ti) has stable and crystalline structure. TGA showed the nanocarrier was stable up to 520°C. Overall, the use of polymer coated MOFs, especially NH₂-MIL-125 (Ti), presents a promising candidate for advancing controlled and effective drug delivery in cancer treatment, offering potential benefits in terms of both efficiency and reduced adverse effects.