Narasimhan, SrinivasanMaheshwaran, ShanmugamAbu-Yousef, ImadMajdalawieh, AminRethavathi, JanarthanamDas, Prince EdwinPoltronieri, Palmiro2022-10-252022-10-252017Narasimhan, S.; Maheshwaran, S.; Abu-Yousef, I.A.; Majdalawieh, A.F.; Rethavathi, J.; Das, P.E.; Poltronieri, P. Anti-Bacterial and Anti-Fungal Activity of Xanthones Obtained via Semi-Synthetic Modification of α-Mangostin from Garcinia mangostana. Molecules 2017, 22, 275. https://doi.org/10.3390/molecules22020275 [This article belongs to the Special Issue Frontiers in Antimicrobial Drug Discovery and Design]1420-3049http://hdl.handle.net/11073/25048The microbial contamination in food packaging has been a major concern that has paved the way to search for novel, natural anti-microbial agents, such as modified α-mangostin. In the present study, twelve synthetic analogs were obtained through semi-synthetic modification of α-mangostin by Ritter reaction, reduction by palladium-carbon (Pd-C), alkylation, and acetylation. The evaluation of the anti-microbial potential of the synthetic analogs showed higher bactericidal activity than the parent molecule. The anti-microbial studies proved that I E showed high anti-bacterial activity whereas I I showed the highest anti-fungal activity. Due to their microbicidal potential, modified α-mangostin derivatives could be utilized as active anti-microbial agents in materials for the biomedical and food industry.en-USSemi-synthetic modificationBiomedical deviceTextilesPackagingAnti-fungalAnti-bacterialα-MangostinArticle10.3390/molecules22020275