Salkho, NajlaTurki, RenadGuessoum, O.Martins, Ana M.Vitor, Rute F.Husseini, Ghaleb2024-04-182024-04-182017Salkho NM, Turki RZ, Guessoum O, Martins AM, Vitor RF, Husseini GA. Liposomes as a Promising Ultrasound-Triggered Drug Delivery System in Cancer Treatment. Curr Mol Med. 2017;17(10):668-688. doi: 10.2174/1566524018666180416100142. PMID: 29663885.1566-5240http://hdl.handle.net/11073/25514The initial uses of ultrasound waves in the medical field were limited to the thermal ablation of solid tumors and as a diagnostic tool. Recent advances at the preclinical stage have allowed the use of ultrasound as a powerful tool to improve drug delivery when the agent is administered encapsulated inside a nanoparticle. This spatial and temporal control of drug release, using a non-invasive modality, is a promising approach to decrease the side effects of conventional chemotherapy in cancer treatments, as it reduces the interaction of the anti-neoplastic agent with healthy tissues. In this review, we explain the physics of ultrasound, introduce and discuss several examples on the use of nanoparticles as drug carriers, with a focus on liposomes. Examples of in vitro and in vivo studies are presented and discussed.en-USCancerAnti-neoplastic agentDrug deliveryDrug ReleaseLiposomesUltrasoundArticle10.2174/1566524018666180416100142