Sabouni, RanaAljassim, Tasneem Jassim2024-09-232024-09-232024-0535.232-2024.22https://hdl.handle.net/11073/25611A Master of Science thesis in Chemical Engineering by Tasneem Jassim Aljassim entitled, “Polymer-Coated Metal Organic Framework for Drug Delivery”, submitted in May 2024. Thesis advisor is Dr. Rana Sabouni. Soft copy is available (Thesis, Completion Certificate, Approval Signatures, and AUS Archives Consent Form).In this Thesis, a nanocarrier has been designed to deliver an anticancer drug with a good loading capacity and release efficiency. The Doxorubicin hydrochloride drug (DOX) was loaded into MIL-53(Al) MOF and two different polymers were used to coat the loaded MOFs separately, Sodium alginate (SA) and Polyvinyl alcohol (PVA) polymers to ensure the drug is protected from leaking out through the delivery process. Both 7.4 and 5.3 pH environments were used to test the DOX release from the nanocarrier. In addition, UV light was employed as an external stimulus to test the drug release. For Sodium alginate polymer coated nanocarriers (DOX@ MIL-53(Al)@SA), the average release of the drug was observed to be 27.27% and 30.92% at 5.3 and 7.4 pH, respectively, when exposed to UV light. However, under a controlled environment (water bath of 37 C°), it was observed to be 8.30% and 7.34% at 5.3 and 7.4 pH, respectively. When exposed to UV light, the average drug release for Polyvinyl alcohol polymer coated nanocarriers (DOX@ MIL-53(Al)@PVA) was 26.4% and 5.54% at 5.3 and 7.4 pH, correspondingly. In a controlled environment (water bath of 37 C°), it was observed to be 8.02% and 5.31% at 5.3 and 7.4 pH, respectively. A shaking experiment was also done on DOX@MIL-53(Al)@SA, DOX@MIL-53(Al)@PVA, and DOX@MIL-53(Al) to test the drug release at pH 7.4. We observed that PVA-coated nanoparticles showed the least release indicating that PVA polymer is pH and Light responsive polymer. Different characterization tests were performed, XRD, TGA, BET, EDX, SEM, and FTIR on (DOX@MIL-53(Al)@SA) and (DOX@MIL-53(Al)@PVA) samples before and after coating to confirm the efficiency of the delivery process of the guest molecule (DOX). Each advancement in drug delivery technology makes cancer treatment more targeted and less invasive. As a result of our commitment to improve drug delivery methods, our goal is to increase the effectiveness of anticancer therapies.en-USMetal organic frameworksDrug deliveryLight responsive nanocarriersUV responsive nanomaterialsDoxorubicin controlled releaseThesis