Loading...
Kinetics of acoustic release of doxorubicin from stabilized and unstabilized micelles and the effect of temperature
Husseini, Ghaleb Diaz de la Rosa, Mario A. AlAqqad, Emad O. Al Mamary, Saif Kadimati, Yaman Al Baik, Abdullah Pitt, William G.
Husseini, Ghaleb
Diaz de la Rosa, Mario A.
AlAqqad, Emad O.
Al Mamary, Saif
Kadimati, Yaman
Al Baik, Abdullah
Pitt, William G.
Date
2011
Advisor
Type
Peer-Reviewed
Article
Postprint
Article
Postprint
Degree
Description
Abstract
Ultrasound is being investigated as a trigger mechanism to deliver high concentrations of chemotherapy drugs to cancerous tissues using polymeric micelles. In this paper, we examined the kinetics of acoustic release of doxorubicin using stabilized and non-stabilized micelles. Kinetic models were used to regress release and re-encapsulation time constants for three different compounds, namely non-stabilizedռ Pluronic® P105 micelles, P105 micelles stabilized using an interpenetrating network of N,N-diethylacrylamide and micelles formed by PEO-b-poly(NIPAAm-co-HEMA-lactate ռ). Results showed that the kinetic release constant (kᵣ) depends on the micellar system under investigation. On the other hand, there is no statistically significant difference between re-encapsulation rate constants for stabilized and unstabilized micelles. We hypothesize that kᵣ depends on the degree of cross-linking or stabilization.