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Item Open Access Encapsulation, Release, and Cytotoxicity of Doxorubicin Loaded in Liposomes, Micelles, and Metal-Organic Frameworks: A Review(MDPI, 2022-01-22)Doxorubicin (DOX) is one of the most widely used anthracycline anticancer drugs due to its high efficacy and evident antitumoral activity on several cancer types. However, its effective utilization is hindered by the adverse side effects associated with its administration, the detriment to the patients’ quality of life, and general toxicity to healthy fast-dividing cells. Thus, delivering DOX to the tumor site encapsulated inside nanocarrier-based systems is an area of research that has garnered colossal interest in targeted medicine. Nanoparticles can be used as vehicles for the localized delivery and release of DOX, decreasing the effects on neighboring healthy cells and providing more control over the drug’s release and distribution. This review presents an overview of DOX-based nanocarrier delivery systems, covering loading methods, release rate, and the cytotoxicity of liposomal, micellar, and metal organic frameworks (MOFs) platforms.Item Open Access Stability analysis of charged neutron stars and Darmois junction conditions(Springer, 2024)This research article examines the impact of theory on the geometry of charged neutron stars filled with anisotropic matter configuration. Here, represents non-metricity and denotes the trace of energy-momentum tensor. We use a particular functional form of this modified theory to reduce the system’s complexity and derive explicit relations of the energy density and pressure components. Further, we consider viable non-singular solutions to analyze the internal structure of the charged neutron stars. The unspecified parameters in the metric coefficients are evaluated through Darmois junction conditions, which ensures consistency between interior and exterior solutions of the stellar objects. These parameters are then used to explore different physical characteristics such as the behavior of energy density, pressure components, anisotropy, energy bounds, equation of state parameter, compactness and redshift function in the interior of charged neutron stars. The stability and equilibrium states of the charged stellar objects are discussed using the Tolman–Oppenheimer–Volkoff equation and the speed of sound, respectively. Our results suggest that the charged neutron stars are viable and stable in the presence of dark source terms.Item Open Access Parametric Study of Methyl Orange Removal Using Metal–Organic Frameworks Based on Factorial Experimental Design Analysis(MDPI, 2022-06-24)Wastewater treatment plants (WWTPs) are one of the most energy-intensive industries. Every stage of wastewater treatment consumes energy, which is the primary contributor to WWTP costs. Adsorbents and process optimization are critical for energy savings. The removal of dyes from industrial wastewater by adsorption using commercially available adsorbents is inefficient. Metal–organic frameworks (MOFs) have outstanding properties that can improve separation performance over current commercial adsorbents, and thus, these materials represent a milestone in improving dye removal in water treatment methods. In this work, three types of metal–organic frameworks (Fe-BTC, Cu-BTC, and ZIF-8) have been investigated as prospective adsorbents for methyl orange removal from water in batch setups. The results showed that at 15 mg/L MO initial concentration and 100 mg dosage, Fe-BTC had the highest removal efficiency of 91%, followed by ZIF-8 (63%), and finally Cu-BTC (35%), which exhibited structural damage due to its instability in water. Fe-BTC maintained consistent adsorption capacity over a wide range of pH values. Furthermore, a 23 full factorial design analysis was implemented to evaluate the conditions for maximum MO-removal efficiency. The main effects, interaction effects, analysis of variance (ANOVA), and the Pareto chart were reported. The statistical analysis demonstrated that the MOF type was the most significant factor, followed by dosage and initial concentration. The analysis indicated that the type of MOF and dosage had a positive effect on the removal efficiency, while the initial concentration had a negative effect. The two-way and three-way interactions were also found to be significant.Item Embargo Trust in the Government, Political Beliefs and its Impact on Energy Poverty(2025-12)This thesis examines the relationship between Trust in the Government, Political Ideology, and Energy Poverty between developed and developing nations based on the panel data of World Values Survey and World Development Indicators. Energy poverty is determined using rates of Electricity access and the consumption per capita. The statistical investigation shows that there is a strong and evident international trend: the increase in electricity consumption is always associated with the self-positioning of the leftist ideology. This is a relationship that is very strong and stable in developing nations and continues (although in lesser intensity) in the richer nations. Conversely, simple access to electricity has no stable correlation with left right political position. Findings on the topic of institutional trust (Wolf) in the form of confidence in political parties and democratic support are exceedingly unstable across specifications and subsamples, with most coefficients changing radically in direction and magnitude, which is evidence of a high level of specification sensitivity as well as overfitting. This analysis does not result in trust as a reliable approach to energy poverty. Generally, the results imply that the high-energy abundance, in the form of the increased consumption but not the mere access, is tightly linked to the political ideology oriented to the left across the world, most prominently, not within the Organisation for Economic Co-operation and Development. An institutional trust and democratic attitudes, however, do not exhibit any consistent and credible impacts to the energy poverty reduction in the current research.Item Embargo Mobile Energy Storage Systems for Benefit Maximization in Resilient Smart Grids(2025-04)modernization of electrical grids, driven by the increasing integration of renewable energy resources, presents significant challenges in maintaining grid stability and reliability. Additionally, the frequency and intensity of natural disasters have increased in recent years due to climate change, further complicating efforts to ensure continuous and resilient power supply. Due to these factors, the implementation of energy storage systems has become essential to enhance grid resilience and support reliable energy delivery. In this context, Mobile Energy Storage Systems (MESS) are explored as a versatile and transporTable solution, capable of connecting to the grid at specific substations to provide a range of critical utility services. These services include load leveling, load shifting, minimizing losses, engaging in energy arbitrage, enhancing overall system reliability and resilience. With the growing need for reliable and cost-effective electricity, the optimal deployment of MESS is becoming increasingly critical. This work presents a hybrid optimization algorithm designed to improve the sizing, storage type selection, and allocation of MESS for multi-service applications, significantly enhancing system performance, reducing outage impacts, and optimizing energy arbitrage. The methodology integrates a dynamic MES model that considers capacity and lifespan constraints with a comprehensive network power flow model, which captures load variation and market price fluctuations. Additionally, the approach includes optimizing repair crew routes, ensuring efficient response to system failures and minimizing downtime. Given the complexity of this mixed-integer nonlinear programming (MINLP) problem, a hybrid technique is employed, combining a Genetic Algorithm for optimal sizing and type selection with mathematical optimization for precise allocation and operational scheduling. This hybrid approach enables more reliable and cost-effective MES management, addressing both operational and economic objectives in energy storage applications. Simulation results on a typical distribution network indicate that the optimized solution for the MESS is a configuration of 32 lithium-ion units, that achieved an energy loss reduction by up to 5.8%, an improvement in system reliability, reflecting in reduced yearly costs of interruptions by 25%, and reduction in the yearly cost of interruptions due to disasters by 9.5%. These results underline the potential financial and operational benefits of deploying MESS in modern electrical networks.
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