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The Use of Modified Composite Zeolite as A Novel Approach to Dental Hygiene Formulation
Rahman, Sumaita
Rahman, Sumaita
Description
A Master of Science thesis in Chemical Engineering by Sumaita Rahman entitled, “The Use of Modified Composite Zeolite as A Novel Approach to Dental Hygiene Formulation”, submitted in May 2024. Thesis advisor is Dr. Taleb Ibrahim and thesis co-advisor is Dr. Sarah Dalibalta. Soft copy is available (Thesis, Completion Certificate, Approval Signatures, and AUS Archives Consent Form).
Abstract
The modern era and its advanced technologies have led to a significant change in the way we live and what we eat. This has increased global expenditure in dental procedures and the 4th most expensive disease to treat. Bacillus cereus, Serratia marcescens, Escherichia coli, and Streptococcus pneumoniae have been strongly associated with the causes of oral diseases. Research even shows the adverse effects of the discussed strains outside the oral cavity. Hence, it is urgent to find a solution that is both economically viable and medicinally valuable. The complexation of cationic surfactants and smectite clays has been explored and one example of such a combination is that of Cetylpyridinium chloride (CPC) with montmorillonite. This study focuses on formulating a novel composite of CPC and zeolite, assessing its surface morphology, chemical composition, stability, and investigating the anti-bacterial properties of the composite along with viability with HBEC-5i cells. CPC-Zt-Alg beads have shown 100% bactericidal activity against all the strains tested and 5.9% toxic to HBEC-5i cells making it a promising material to be used in the medical industry with its high anti-bacterial activity and low cytotoxicity.